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John J P Kastelein Selected Research

Inflammation (Inflammations)

4/2022A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH.
11/2020Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative.
1/2019Association of Initial and Serial C-Reactive Protein Levels With Adverse Cardiovascular Events and Death After Acute Coronary Syndrome: A Secondary Analysis of the VISTA-16 Trial.
1/2018Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial: A Randomized Clinical Trial.
1/2017Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study.
1/2017Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
10/2014Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia.
12/2013Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs.
4/2012Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial.
3/2012Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
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John J P Kastelein Research Topics

Disease

130Cardiovascular Diseases (Cardiovascular Disease)
05/2024 - 01/2002
110Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
05/2024 - 07/2002
77Coronary Artery Disease (Coronary Atherosclerosis)
04/2024 - 05/2002
77Atherosclerosis
04/2024 - 01/2002
62Coronary Disease (Coronary Heart Disease)
01/2019 - 04/2002
42Myocardial Infarction
04/2024 - 12/2002
24Inflammation (Inflammations)
04/2022 - 12/2002
23Stroke (Strokes)
04/2024 - 04/2005
22Dyslipidemias (Dyslipidemia)
05/2024 - 10/2004
21Hypercholesterolemia
09/2020 - 10/2003
17Atherosclerotic Plaque (Atheroma)
01/2021 - 02/2006
17Hypertension (High Blood Pressure)
07/2018 - 06/2004
13Homozygous Familial Hypercholesterolemia
10/2023 - 03/2014
13Neoplasms (Cancer)
01/2019 - 09/2004
12Hypertriglyceridemia
03/2024 - 09/2004
12Metabolic Syndrome (Dysmetabolic Syndrome X)
03/2013 - 04/2005
11Injection Site Reaction
09/2020 - 08/2007
11Vascular Diseases (Vascular Disease)
11/2016 - 12/2002
10Hyperlipidemias (Hyperlipidemia)
01/2022 - 02/2002
10Type 2 Diabetes Mellitus (MODY)
05/2021 - 12/2004
10Acute Coronary Syndrome
01/2019 - 04/2005
10Diabetes Mellitus
01/2018 - 11/2005
10Carotid Artery Diseases
12/2013 - 05/2003
9Unstable Angina
01/2019 - 11/2008
8Insulin Resistance
11/2022 - 07/2007
7Inborn Genetic Diseases (Disease, Hereditary)
10/2023 - 04/2005
7Hypoalphalipoproteinemias (Hypoalphalipoproteinemia)
12/2014 - 10/2002
6Body Weight (Weight, Body)
01/2020 - 05/2007
6Heart Failure
12/2015 - 02/2007
5Pancreatitis
12/2019 - 09/2004
5Hypotension (Low Blood Pressure)
11/2016 - 04/2005
5Abdominal Obesity
07/2011 - 01/2008
4Chronic Renal Insufficiency
01/2019 - 12/2006
4Infections
01/2017 - 10/2004
4Heart Arrest (Cardiac Arrest)
04/2012 - 04/2005

Drug/Important Bio-Agent (IBA)

126Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
04/2024 - 07/2002
100LDL CholesterolIBA
10/2023 - 04/2002
92LipidsIBA
05/2024 - 10/2002
79oxidized low density lipoproteinIBA
05/2024 - 04/2002
68HDL CholesterolIBA
04/2024 - 05/2002
48CholesterolIBA
04/2024 - 01/2002
38Lipoproteins (Lipoprotein)IBA
05/2024 - 08/2002
36Atorvastatin (Lipitor)FDA Link
04/2024 - 12/2002
29Triglycerides (Triacylglycerol)IBA
04/2024 - 06/2004
29ApolipoproteinsIBA
11/2023 - 06/2003
27Apolipoproteins B (ApoB)IBA
11/2022 - 10/2003
26LDL Lipoproteins (beta Lipoproteins)IBA
01/2023 - 10/2003
25Apolipoprotein A-I (Apolipoprotein A1)IBA
04/2024 - 10/2004
24Biomarkers (Surrogate Marker)IBA
01/2016 - 12/2002
23Simvastatin (Zocor)FDA LinkGeneric
03/2013 - 07/2002
22Cholesterol Ester Transfer ProteinsIBA
05/2024 - 01/2003
22C-Reactive ProteinIBA
01/2019 - 12/2002
20HDL LipoproteinsIBA
04/2024 - 08/2004
18LDL Receptors (LDL Receptor)IBA
01/2019 - 12/2002
15Pravastatin (Pravachol)FDA LinkGeneric
10/2019 - 05/2003
13Rosuvastatin Calcium (Crestor)FDA Link
04/2024 - 03/2003
13Ezetimibe (Zetia)FDA Link
10/2023 - 02/2005
12Proprotein Convertase 9IBA
10/2023 - 06/2014
12alirocumabIBA
09/2020 - 06/2014
12Trinitrotoluene (TNT)IBA
11/2016 - 09/2006
10Proteins (Proteins, Gene)FDA Link
04/2024 - 10/2003
9mipomersenIBA
01/2021 - 05/2010
9Lipoprotein Lipase (Diacylglycerol Lipase)IBA
01/2019 - 09/2004
8Lipoprotein(a)IBA
03/2024 - 06/2004
8EnzymesIBA
11/2023 - 06/2006
8Glucose (Dextrose)FDA LinkGeneric
11/2022 - 06/2004
7torcetrapibIBA
11/2012 - 04/2007
6Insulin (Novolin)FDA Link
06/2023 - 09/2009
6evolocumabIBA
10/2022 - 06/2016
6dalcetrapibIBA
12/2014 - 05/2002
5CSL112IBA
04/2024 - 10/2016
5CreatinineIBA
11/2023 - 12/2006
5ALN-PCSIBA
10/2023 - 01/2017
5Monoclonal AntibodiesIBA
09/2022 - 06/2014
5DNA (Deoxyribonucleic Acid)IBA
08/2017 - 05/2004
5Secretory Phospholipases A2IBA
01/2014 - 04/2005
5AdiponectinIBA
01/2012 - 01/2008
5Adenosine Triphosphate (ATP)IBA
10/2011 - 10/2002
4bococizumabIBA
07/2018 - 08/2016
4CER-001IBA
01/2018 - 12/2014
4lipoprotein cholesterolIBA
11/2016 - 04/2005
4Phytosterols (Plant Sterols)IBA
12/2014 - 12/2005
4Aryldialkylphosphatase (Paraoxonase)IBA
08/2009 - 02/2005
3Small Interfering RNA (siRNA)IBA
10/2023 - 01/2019
3Fatty Acids (Saturated Fatty Acids)IBA
04/2022 - 01/2016
3icosabutateIBA
04/2022 - 01/2016
3Eicosapentaenoic AcidIBA
04/2022 - 01/2014
3Nonesterified Fatty Acids (NEFA)IBA
01/2022 - 01/2012
3BMS201038IBA
01/2021 - 03/2014
3Phospholipids (Phosphatides)FDA LinkGeneric
11/2020 - 05/2006
3omega-Chloroacetophenone (Mace)IBA
01/2019 - 12/2015
3varespladibIBA
01/2019 - 04/2011
3Apolipoprotein C-IIIIBA
11/2018 - 07/2015

Therapy/Procedure

99Therapeutics
05/2024 - 08/2002
10Secondary Prevention
01/2021 - 11/2005
5Resuscitation
06/2013 - 04/2005
4Blood Component Removal (Apheresis)
10/2023 - 10/2014
4Drug Therapy (Chemotherapy)
01/2021 - 06/2004
4Subcutaneous Injections
01/2021 - 12/2016
3Intravenous Infusions
01/2020 - 01/2018